AmoyDx HANDLE Insight NGS Panel

Research-use HANDLE NGS panel for endometrial cancer molecular classification and hereditary cancer risk screening. It detects SNVs and InDels in 10 genes (BRCA1, BRCA2, CTNNB1, EPCAM, MLH1, MSH2, MSH6, PMS2, POLE, TP53), BRCA1/2 copy number variation from blood and MSI status from tumour tissue, covering Lynch syndrome and hereditary breast and ovarian cancer genes. Accepts peripheral whole blood and FFPE tissue, runs on Illumina iSeq 100, MiniSeq, MiSeq/MiSeqDx and NextSeq 500/550, and needs under 5 hours of library preparation; 24 tests per kit.

Target Genes

10 genes (BRCA1, BRCA2, CTNNB1, EPCAM, MLH1, MSH2, MSH6, PMS2, POLE, TP53)

Sample Types

peripheral whole blood and FFPE tissue

Compatible Sequencers

Illumina iSeq 100, MiniSeq, MiSeq/MiSeqDx and NextSeq 500/550

Library Preparation Time

under 5 hours

Kit Size

24 tests per kit