AmoyDx HANDLE Hereditary Cancer NGS Panel

Research-use germline NGS panel built on HANDLE one-tube technology for hereditary cancer risk assessment from peripheral whole blood DNA. It covers 150 cancer susceptibility genes for SNVs and InDels and detects large rearrangement deletions in 8 genes: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM and VHL. Compatible with Illumina NovaSeq 6000, NextSeq 500, NextSeq 550Dx, MiSeq/MiSeqDx and Salus Pro, with under 1 hour hands-on time and under 5 hours library preparation.

Target application

Hereditary cancer risk assessment

Sample type

Peripheral whole blood DNA

Gene coverage

150 cancer susceptibility genes for SNVs and InDels

Large rearrangement deletion detection

8 genes: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM and VHL

Platform compatibility

Illumina NovaSeq 6000, NextSeq 500, NextSeq 550Dx, MiSeq/MiSeqDx and Salus Pro

Hands-on time

Under 1 hour

Library preparation time

Under 5 hours